The game is about a man named Freeze, his friend Shaun Calderon, and police officer Lester Williams in the fictional city of Las Ruinas. Freeze commits crimes with Shaun to get money, which he spends for his family, while Williams is trying to stop the organized crime and across the city.
One night upon returning home, his wife confronts him about these actions. Saying they are a bad influence to their son, she wants him to stop. After an argument, he agrees. The next day, he tells Shaun he wants out of the game. Shaun levels a gun on Freeze, informing him that he must do one last job, a narcotics trade.
At the deal, Freeze finds the Colombian gang members dead and police officer Maria Mendoza waiting. Freeze flees with the police in pursuit and loses them. The 2nd Street D-Boys realize Freeze wants out of the gang and he has to avoid both his former gang and the police. Later, he robs a bank. After a gun fight against the police, he reaches his getaway car, only to be arrested after being hit by a nightstick.
Meanwhile, Mendoza informs Williams of Shaun. They look for Shaun in his house, but get caught in a gun fight. Williams finds evidence and goes to a club to find Shaun, chasing him to the subway. The chase ends with Williams arresting Shaun, but Mendoza kills him and tells Shaun to leave for Mexico.
Shaun goes to Tijuana and fights his way to a local club called "The Curtains Club". He robs a casino, fights security, and goes to a wealthy man named Saragosa in his penthouse, who he kills.
Freeze breaks out of jail and gets new clothes at the mall while being chased by the police. He kills Mendoza in the mall and hunts down Shaun, now a wealthy drug kingpin, eventually stepping on Shaun's neck until he suffocates. The final scene shows Freeze telling Darnell, "From now on, it's just you and me against the world. Now let's do this", as a large number of police officers arrive, with Freeze picking up a gun and pointing it at the police.
